Bundesliga:
| Freitag 16 April 2021 | ||
| RB Leipzig | 20:30 | TSG 1899 Hoffenheim |
| Samstag 17 April 2021 | ||
| Borussia Mönchengladbach | 15:30 | Eintracht Frankfurt |
| Wolfsburg | 15:30 | Bayern Munich |
| SC Freiburg | 15:30 | Schalke 04 |
| Union Berlin | 15:30 | Stuttgart |
| Augsburg 1907 | 15:30 | Arminia Bielefeld |
| Bayer 04 Leverkusen | 18:30 | 1. FC Köln |
| Sonntag 18 April 2021 | ||
| Borussia Dortmund | 15:30 | Werder Bremen |
| 1. FSV Mainz 05 | 18:00 | Hertha BSC |
| Dienstag 20 April 2021 | ||
| 1. FC Köln | 18:30 | RB Leipzig |
| Bayern Munich | 20:30 | Bayer 04 Leverkusen |
| Eintracht Frankfurt | 20:30 | Augsburg 1907 |
| Arminia Bielefeld | 20:30 | Schalke 04 |
| Mittwoch 21 April 2021 | ||
| Hertha BSC | 18:30 | SC Freiburg |
| Borussia Dortmund | 20:30 | Union Berlin |
| TSG 1899 Hoffenheim | 20:30 | Borussia Mönchengladbach |
| Werder Bremen | 20:30 | 1. FSV Mainz 05 |
| Stuttgart | 20:30 | Wolfsburg |
| Freitag 23 April 2021 | ||
| Augsburg 1907 | 20:30 | 1. FC Köln |
Bundesliga Ergebnisse:
| # | Mannschaft | Spiele | S | U | N | T | GT | TD | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Bayern Munich | 28 | 20 | 5 | 3 | 80 | 36 | +44 | 65 |
| 2 | RB Leipzig | 28 | 18 | 6 | 4 | 52 | 23 | +29 | 60 |
| 3 | Wolfsburg | 28 | 15 | 9 | 4 | 49 | 26 | +23 | 54 |
| 4 | Eintracht Frankfurt | 28 | 14 | 11 | 3 | 59 | 40 | +19 | 53 |
| 5 | Borussia Dortmund | 28 | 14 | 4 | 10 | 58 | 41 | +17 | 46 |
| 6 | Bayer 04 Leverkusen | 28 | 12 | 8 | 8 | 45 | 32 | +13 | 44 |
| 7 | Union Berlin | 28 | 9 | 13 | 6 | 42 | 34 | +8 | 40 |
| 8 | Borussia Mönchengladbach | 28 | 10 | 10 | 8 | 48 | 43 | +5 | 40 |
| 9 | Stuttgart | 28 | 10 | 9 | 9 | 50 | 44 | +6 | 39 |
| 10 | SC Freiburg | 28 | 10 | 7 | 11 | 40 | 42 | -2 | 37 |
| 11 | Augsburg 1907 | 28 | 9 | 5 | 14 | 29 | 42 | -13 | 32 |
| 12 | TSG 1899 Hoffenheim | 28 | 8 | 7 | 13 | 41 | 47 | -6 | 31 |
| 13 | Werder Bremen | 28 | 7 | 9 | 12 | 32 | 43 | -11 | 30 |
| 14 | 1. FSV Mainz 05 | 28 | 7 | 7 | 14 | 30 | 48 | -18 | 28 |
| 15 | Hertha BSC | 28 | 6 | 8 | 14 | 34 | 48 | -14 | 26 |
| 16 | Arminia Bielefeld | 28 | 7 | 5 | 16 | 22 | 46 | -24 | 26 |
| 17 | 1. FC Köln | 28 | 5 | 8 | 15 | 27 | 50 | -23 | 23 |
| 18 | Schalke 04 | 28 | 2 | 7 | 19 | 18 | 71 | -53 | 13 |