Bundesliga:
| Freitag 24 September 2021 | ||
| Greuther Fürth | 20:30 | Bayern Munich |
| Samstag 25 September 2021 | ||
| Union Berlin | 15:30 | Arminia Bielefeld |
| TSG 1899 Hoffenheim | 15:30 | Wolfsburg |
| RB Leipzig | 15:30 | Hertha Berlin |
| Bayer 04 Leverkusen | 15:30 | Mainz |
| Eintracht Frankfurt | 15:30 | FC Cologne |
| Borussia Mönchengladbach | 18:30 | Borussia Dortmund |
| Sonntag 26 September 2021 | ||
| VFL Bochum | 15:30 | Stuttgart |
| SC Freiburg | 17:30 | Augsburg 1907 |
| Freitag 1 Oktober 2021 | ||
| FC Cologne | 20:30 | Greuther Fürth |
| Samstag 2 Oktober 2021 | ||
| Borussia Dortmund | 15:30 | Augsburg 1907 |
| Wolfsburg | 15:30 | Borussia Mönchengladbach |
| Stuttgart | 15:30 | TSG 1899 Hoffenheim |
| Hertha Berlin | 15:30 | SC Freiburg |
| RB Leipzig | 18:30 | VFL Bochum |
| Sonntag 3 Oktober 2021 | ||
| Mainz | 15:30 | Union Berlin |
| Bayern Munich | 17:30 | Eintracht Frankfurt |
| Arminia Bielefeld | 19:30 | Bayer 04 Leverkusen |
| Freitag 15 Oktober 2021 | ||
| TSG 1899 Hoffenheim | 20:30 | FC Cologne |
Bundesliga Ergebnisse:
| # | Mannschaft | Spiele | S | U | N | T | GT | TD | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Bayern Munich | 5 | 4 | 1 | 0 | 20 | 4 | +16 | 13 |
| 2 | Wolfsburg | 5 | 4 | 1 | 0 | 7 | 2 | +5 | 13 |
| 3 | Borussia Dortmund | 5 | 4 | 0 | 1 | 17 | 11 | +6 | 12 |
| 4 | Bayer 04 Leverkusen | 5 | 3 | 1 | 1 | 15 | 7 | +8 | 10 |
| 5 | Mainz | 5 | 3 | 1 | 1 | 6 | 2 | +4 | 10 |
| 6 | SC Freiburg | 5 | 2 | 3 | 0 | 6 | 4 | +2 | 9 |
| 7 | FC Cologne | 5 | 2 | 2 | 1 | 9 | 7 | +2 | 8 |
| 8 | Union Berlin | 5 | 1 | 3 | 1 | 7 | 8 | -1 | 6 |
| 9 | Hertha Berlin | 5 | 2 | 0 | 3 | 7 | 12 | -5 | 6 |
| 10 | TSG 1899 Hoffenheim | 5 | 1 | 2 | 2 | 8 | 7 | +1 | 5 |
| 11 | Augsburg 1907 | 5 | 1 | 2 | 2 | 2 | 8 | -6 | 5 |
| 12 | RB Leipzig | 5 | 1 | 1 | 3 | 6 | 7 | -1 | 4 |
| 13 | Arminia Bielefeld | 5 | 0 | 4 | 1 | 3 | 5 | -2 | 4 |
| 14 | Stuttgart | 5 | 1 | 1 | 3 | 9 | 12 | -3 | 4 |
| 15 | Eintracht Frankfurt | 5 | 0 | 4 | 1 | 5 | 8 | -3 | 4 |
| 16 | Borussia Mönchengladbach | 5 | 1 | 1 | 3 | 5 | 9 | -4 | 4 |
| 17 | VFL Bochum | 5 | 1 | 0 | 4 | 4 | 13 | -9 | 3 |
| 18 | Greuther Fürth | 5 | 0 | 1 | 4 | 3 | 13 | -10 | 1 |